- May 1562 - French under Jean Ribaut build Charlesfort, Ribaut sails back to France for more men & settlers but his return is delayed
- 1563 - The remaining garrison abandons the settlement & sails for France
- 1564 - Spanish under Manrique de Rojas sent to destroy the abandoned Charlesfort
- Apr 1566 - Pedro Menéndez & some 89 men establish Fort San Salvador
- 1566 - Capt Juan Pardo & 250 more men arrive & build Fort San Felipe
- 1568 - Menéndez begins bringing civilian settlers to the island
- 1576 - 500 Indians attack & the Colony evacuates to San Augustine
- Oct 1577 - Spanish return to build & garrison Fort San Marcos (1)
- 1580 - Spanish Colonists brought back to Santa Elena
- 1583 - New Fort San Marcos (2) built
- 1587 - Spanish Colony abandoned & fort burned
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